4-Chlorobenzoyl chloride → HCID 22147927, compound

HRID 2114941Notes

Reaction equation

HRID 2114941 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH:9][NH:10][C:11](=[O:19])[C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1)=O.ClC1C=CC(C(Cl)=O)=CC=1>>[Cl:18][C:15]1[CH:14]=[CH:13][C:12]([C:11]2[O:19][C:7]([C:3]3[S:4][CH:5]=[CH:6][C:2]=3[Cl:1])=[N:9][N:10]=2)=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 69250121HCID 69250121, compound

Product 1

HCID 22147927HCID 22147927, compound

Procedure

4-Chloro-benzoic acid N′-(3-chloro-thiophene-2-carbonyl)-hydrazide: The title compound was prepared from 3-chloro-thiophene-2-carbonyl hydrazide (70 mg, 0.40 mmol) and 4-chlorobenzoyl chloride (50.5 μL, 0.40 mmol) similar to Example 84b, and yielded 130 mg (100%) of white solid. 1H NMR (DMSO-d6): 10.66 (s, 1H), 10.30 (s, 1H), 7.93 (m, 3H), 7.61 (d, J=8.79 Hz, 1H), 7.22 (d, J=5.22 Hz, 1H).

Sources & evidence

ORD record
ord-20a39fde936b4de88c56030f3c44269a
Source dataset
uspto-grants-2008_10
Patent number
US07435750B2

Reaction notes

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