4-Methylbenzene-1-carboximidamide hydrochloride → HCID 22147896, compound

HRID 2114944Notes

Reaction equation

HRID 2114944 reaction equation
Cl.[CH3:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[NH:8])=[CH:5][CH:4]=1.[Cl:12][C:13]1[CH:17]=[CH:16][S:15][C:14]=1[C:18]([NH:20]N)=O>>[Cl:12][C:13]1[CH:17]=[CH:16][S:15][C:14]=1[C:18]1[NH:20][N:9]=[C:7]([C:6]2[CH:10]=[CH:11][C:3]([CH3:2])=[CH:4][CH:5]=2)[N:8]=1

Participants

3

Reactant 2

HCID 1227534-Methylbenzene-1-carboximidamide hydrochlorideHCID 23570764HCID 23570764, compound

Product 1

HCID 22147896HCID 22147896, compound

Procedure

The title compound was prepared from 4-methyl-benzamidine hydrochloride and 3-chloro-thiophene-2-carboxylic acid hydrazide by a procedure similar to Example 88b as a yellow solid (0.054 g, 17%). 1H NMR (CD3OD): 7.80 (d, J=7.8 Hz, 2H), 7.52 (d, J=6.0 Hz, 1H), 7.22 (d, J=8.4 Hz, 2H), 6.97 (d, J=5.10 Hz, 1H), 2.30 (s, 3H).

Sources & evidence

ORD record
ord-7eb31402bb72447eb8d6abdc437571ed
Source dataset
uspto-grants-2008_10
Patent number
US07435750B2

Reaction notes

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