4-Chlorobenzoyl chloride → HCID 22147913, compound

HRID 2114947Notes

Reaction equation

HRID 2114947 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7](=[O:19])[CH2:8][NH:9][C:10](=O)[C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1.Cl.ClC1C=CSC=1C(=O)CN.ClC1C=CC(C(Cl)=O)=CC=1>>[Cl:17][C:14]1[CH:13]=[CH:12][C:11]([C:10]2[O:19][C:7]([C:3]3[S:4][CH:5]=[CH:6][C:2]=3[Cl:1])=[CH:8][N:9]=2)=[CH:16][CH:15]=1

Participants

4

Reactant 3

HCID 85014-Chlorobenzoyl chlorideHCID 22147878HCID 22147878, compoundHCID 692498842-(3-Chloro-thiophen-2-yl)-2-oxo-1-ethylamine hydrochloride

Product 1

HCID 22147913HCID 22147913, compound

Procedure

N-[2-(3-Chloro-thiophen-2-yl)-2-oxo-ethyl]-4-chloro-benzamide: The title compound was prepared from 2-(3-chloro-thiophen-2-yl)-2-oxo-1-ethylamine hydrochloride (0.05 g, 0.235 mmol) and 4-chloro-benzoyl chloride (0.02 mL, 0.235 mmol) by a procedure similar to Example 97a to yield 0.048 g (72.7%) of white solid. 1H NMR (CD3OD): 7.77 (m, 3H), 7.43 (d, J=8.4 Hz, 2H), 7.36 (t, 1H), 7.05 (d, J=5.4 Hz, 1H), 4.75 (d, J=9.3 Hz, 2H).

Sources & evidence

ORD record
ord-cb3ca7693f6a4ac782919629ec0f228c
Source dataset
uspto-grants-2008_10
Patent number
US07435750B2

Reaction notes

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