p-Chlorophenacyl bromide → HCID 22147904, compound

HRID 2114951Notes

Reaction equation

HRID 2114951 reaction equation
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH2:9])=[O:8].[Cl:10][C:11]1[CH:20]=[CH:19][C:14]([C:15](=O)[CH2:16]Br)=[CH:13][CH:12]=1>>[Cl:10][C:11]1[CH:20]=[CH:19][C:14]([C:15]2[N:9]=[C:7]([C:3]3[S:4][CH:5]=[CH:6][C:2]=3[Cl:1])[O:8][CH:16]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 68303p-Chlorophenacyl bromideHCID 28080883-chlorothiophene-2-carboxamide

Product 1

HCID 22147904HCID 22147904, compound

Procedure

The title compound was prepared from 3-chloro-thiophene-2-carboxamide (0.100 g, 1.03 mmol) and 4-chloro-phenacyl bromide (0.200 g, 0.856 mmol) by a procedure similar to Example 101 as a white solid (0.006 g, 3.2%). 1H NMR (Acetone-d6): 8.45 (s, 1H), 7.80 (d, J=6.6 Hz, 2H), 7.70 (d, J=6.0 Hz, 1H), 7.38 (d, J=8.1 Hz, 2H), 7.08 (d, J=6.0 Hz, 1H).

Sources & evidence

ORD record
ord-781824ff0d6a45bf8eda9ab7667e75b9
Source dataset
uspto-grants-2008_10
Patent number
US07435750B2

Reaction notes

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