2-Hydrazinopyridine → HCID 22147911, compound

HRID 2114955Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)[N:11]=[C:10]([C:19]3[S:20][CH:21]=[CH:22][C:23]=3[Cl:24])[CH2:9]2)=[CH:4][CH:3]=1.N(C1C=CC=CN=1)N>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)[N:11]=[C:10]([C:19]3[S:20][CH:21]=[CH:22][C:23]=3[Cl:24])[CH:9]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 786452-Hydrazinopyridine

HCID 22147894HCID 22147894, compound

Product 1

HCID 22147911HCID 22147911, compound

Procedure

5-(4-Chloro-phenyl)-3-(3-chloro-thiophen-2-yl)-1-(pyridin-2-yl)-4,5-dihydro-1H-pyrazole: The title compound was prepared from 3-(4-chloro-phenyl)-1-(3-chloro-thiophen-2-yl)-propenone and 2-hydrazinopyridine by a procedure similar to that of Example 105a as a yellowish oil (141 mg, 73.8%). 1H NMR (CDCl3): 8.04 (m, 1H), 7.59 (t, 1H), 7.46 (d, J=9.0 Hz, 1H), 7.27 (m, 6H), 6.92 (d, J=5.4 Hz, 1H), 6.68 (t, 1H), 4.01 (t, 1H), 3.41 (m, 1H).

Sources & evidence

ORD record: ord-ce33e86a3bbe4522b38996009dc903ad
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07435750B2

Reaction notes

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