4-Hydrazinobenzoic acid → HCID 22147916, compound

HRID 2114956Notes

Reaction equation

HRID 2114956 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([C:19]([OH:21])=[O:20])=[CH:15][CH:14]=3)[N:11]=[C:10]([C:22]3[S:23][CH:24]=[CH:25][C:26]=3[Cl:27])[CH2:9]2)=[CH:4][CH:3]=1.N(C1C=CC(C(O)=O)=CC=1)N>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]([C:13]3[CH:14]=[CH:15][C:16]([C:19]([OH:21])=[O:20])=[CH:17][CH:18]=3)[N:11]=[C:10]([C:22]3[S:23][CH:24]=[CH:25][C:26]=3[Cl:27])[CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 120894-Hydrazinobenzoic acidHCID 22147910HCID 22147910, compound

Product 1

HCID 22147916HCID 22147916, compound

Procedure

5-(4-Chloro-phenyl)-3-(3-chloro-thiophen-2-yl)-1-(4-carboxy-phenyl)4,5-dihydro-pyrazole: The title compound was prepared from 3-(4-chloro-phenyl)-1-(3-chloro-thiophen-2-yl)-propenone and 4-hydrazinobenzoic acid by a procedure similar to that of Example 105a as a yellowish oil (166 mg, 74%). 1H NMR (CDCl3): 9.02 (s, 1H), 7.92-6.80 (m, 10H), 5.72 (m, 1H), 4.20 (m, 1H), 4.01 (t, 1H), 3.41 (m, 1H).

Sources & evidence

ORD record
ord-71c71a66f092464786a339ade691d611
Source dataset
uspto-grants-2008_10
Patent number
US07435750B2

Reaction notes

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