HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-amino-1,3-benzoxazol-2(3H)-one → 2-{4-[(4-Fluorophenyl)methyl]piperidin-1-yl}-N-(2-hydroxy-1,3-benzoxazol-6-yl)-2-oxoacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-amino-1,3-benzoxazol-2(3H)-one | HCID 826989 | — |
| Reactant | [4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acid | HCID 51342220 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-{4-[(4-Fluorophenyl)methyl]piperidin-1-yl}-N-(2-hydroxy-1,3-benzoxazol-6-yl)-2-oxoacetamide | HCID 10200813 | — |
Reaction Steps
The title compound is prepared from [4-(4-fluoro-benzyl)-piperidin-1-yl]-oxo-acetic acid (Example 1b) and 6-amino-3H-benzoxazol-2-one [J. Chem. Soc.,321. (1938)] according to the method described in Example 1c. Melting Point: 224-227° C. (diethylether)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435744B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-228d1adb54b94cf18a0dc87d93dd2727 |
| Source note | uspto-grants-2008_10 |