HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-amino-3,4-dihydro-2H-1,4-benzoxazin-3-one → 2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-yl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-amino-3,4-dihydro-2H-1,4-benzoxazin-3-one | HCID 2764182 | — |
| Reactant | [4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acid | HCID 51342220 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-yl)-acetamide | HCID 69100294 | — |
Reaction Steps
The title compound is prepared from 7-amino-4H-benzo[1,4]oxazin-3-one [J. Med. Chem., 32, 1627. (1989)] and [4-(4-fluoro-benzyl)-piperidin-1-yl]-oxo-acetic acid (Example 1b) according to the method described in Example 2. Melting Point: 209-212° C. (diethylether)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435744B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-a4539e1ee9294ca29e440a2667a4b117 |
| Source note | uspto-grants-2008_10 |