[4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acid → HCID 178521823, compound

HRID 2114979Notes

Reaction equation

HRID 2114979 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[F:11][C:12]1[CH:29]=[CH:28][C:15]([CH2:16][CH:17]2[CH2:22][CH2:21][N:20]([C:23](=[O:27])[C:24](O)=[O:25])[CH2:19][CH2:18]2)=[CH:14][CH:13]=1>C(OCC)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH:10][C:24](=[O:25])[C:23]([N:20]3[CH2:19][CH2:18][CH:17]([CH2:16][C:15]4[CH:14]=[CH:13][C:12]([F:11])=[CH:29][CH:28]=4)[CH2:22][CH2:21]3)=[O:27])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 51342220[4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acidHCID 178507353HCID 178507353, compound

Product 1

HCID 178521823HCID 178521823, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from (1H-benzimidazol-5yl) amine [Synth. Commun., 29, 2435. (1999)] and [4-(4-fluoro-benzyl)-piperidin-1-yl]-oxo-acetic acid Example 1b) according to the method described in Example 1c. Melting Point: 104-110° C. (diethylether)

Sources & evidence

ORD record
ord-d74f47bc9cda4f8caf0e54c790e01df0
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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