HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-oxindole → 2-Oxo-N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-2-(4-p-tolyloxy-piperidin-1-yl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-oxindole | HCID 2773213 | — |
| Reactant | Oxo-(4-p-tolyloxy-piperidin-1-yl)-acetic acid | HCID 69100252 | — |
| Product | 2-Oxo-N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-2-(4-p-tolyloxy-piperidin-1-yl)-acetamide | HCID 69100718 | — |
Reaction Steps
The title compound is prepared from oxo-(4-p-tolyloxy-piperidin-1-yl)-acetic acid and 5-amino-1,3-dihydro-indol-2-one according to the method described in Example 2. The filtered crystals are purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and toluene:methanol=4:1 as eluent. Melting Point: 176-178° C. (diethyl ether)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435744B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-52765ca6e0a44ddea76137d35145b8fb |
| Source note | uspto-grants-2008_10 |