5-Amino-2-oxindole → HCID 69100613, compound

HRID 2114984Notes

Reaction equation

HRID 2114984 reaction equation
[O:1]=[C:2]([N:6]1[CH2:11][CH2:10][CH:9]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:7]1)[C:3]([OH:5])=O.[NH2:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[NH:25][C:24](=[O:29])[CH2:23]2>>[O:1]=[C:2]([N:6]1[CH2:11][CH2:10][CH:9]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:7]1)[C:3]([NH:19][C:20]1[CH:21]=[C:22]2[C:26](=[CH:27][CH:28]=1)[NH:25][C:24](=[O:29])[CH2:23]2)=[O:5]

Participants

3

Reactant 2

HCID 27732135-Amino-2-oxindoleHCID 69100878HCID 69100878, compound

Product 1

HCID 69100613HCID 69100613, compound

Procedure

The title compound is prepared from oxo-(4-phenoxy-piperidin-1-yl)-acetic acid and 5-amino-1,3-dihydro-indol-2-one according to the method described in Example 2. The filtered crystals are purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and toluene:methanol=4:1 as eluent. Melting Point: 78-81° C. (diethyl ether)

Workup

  1. customThe filtered crystals are purified by column chromatography

Sources & evidence

ORD record
ord-be349580000f4767910f5e871c974fde
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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