5-Amino-2-hydroxybenzimidazole → HCID 10201898, compound

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Reaction Steps

The title compound is prepared from [4-(4-chloro-phenoxy)-piperidin-1-yl]-oxo-acetic acid (Example 29d) and 5-amino-1,3-dihydro-benzimidazol-2-one according to the method described in Example 2. The filtered crystals are purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and chloroform:methanol=10:1 as eluent. Melting Point: 286-288° C. (isopropanol)

Provenance & Evidence