5-Amino-2-hydroxybenzimidazole → HCID 10273143, compound

HRID 2114990Notes

Reaction equation

HRID 2114990 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13](=[O:17])[C:14]([OH:16])=O)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[NH2:20][C:21]1[CH:30]=[CH:29][C:24]2[NH:25][C:26](=[O:28])[NH:27][C:23]=2[CH:22]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][N:10]([C:13](=[O:17])[C:14]([NH:20][C:21]3[CH:30]=[CH:29][C:24]4[NH:25][C:26](=[O:28])[NH:27][C:23]=4[CH:22]=3)=[O:16])[CH2:11][CH2:12]2)=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 667655-Amino-2-hydroxybenzimidazoleHCID 69100700HCID 69100700, compound

Product 1

HCID 10273143HCID 10273143, compound

Procedure

The title compound is prepared from [4-(4-chloro-benzyl)-piperidin-1-yl]-oxo-acetic acid (Example 33b) and 5-amino-1,3-dihydro-benzimidazol-2-one according to the method described in Example 2. The filtered crystals are purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and toluene:methanol=4:1 as eluent. Melting Point: 299-300° C. (isopropanol)

Workup

  1. customThe filtered crystals are purified by column chromatography

Sources & evidence

ORD record
ord-3a635456002840e5a5512ba4c7605839
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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