Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 178452968 | HCID 178452968 | — |
| Product | HCID 69100632 | HCID 69100632 | 97.1% |
Reaction Steps
To a solution of 5 ml of 5% trifluoroacetic acid in dichloromethane 0.8 g (1.67 mmol) of {5-[2-(4-benzyl-piperidin-1-yl)-2-oxo-acetylamino]-1H-benzimidazol-2-yl}-carbamic acid tert-butyl ester is added. The reaction mixture is stirred for 48 hours at 20° C. The precipitated crystals are filtered off and washed with dichloromethane to yield 0.8 g (97.1%) of the title compound. Melting Point: 121° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07435744B2 |
|---|
| Source dataset | uspto-grants-2008_10 |
|---|
| ORD ID | ord-07e1182bb7374d84be5a89eb55c8d332 |
|---|
| Source note | uspto-grants-2008_10 |
|---|
