2,6-Benzothiazolediamine → N-(2-Amino-benzthiazol-6-yl)-2-(4-benzyl-piperidin-1-yl)-2-oxo-acetamide

Participants

Role	Name	HCID	Charge
Reactant	2,6-Benzothiazolediamine	HCID 21504	—
Reactant	(4-Benzylpiperidin-1-yl)oxoacetic acid	HCID 16110264	—
Product	N-(2-Amino-benzthiazol-6-yl)-2-(4-benzyl-piperidin-1-yl)-2-oxo-acetamide	HCID 86593927	—

Reaction Steps

The title compound is prepared from (4-benzyl-piperidin-1-yl)-oxo-acetic acid (Example 5b) and 2,6-diamino-benzthiazole [Arch. Pharm., 13, 48. (1935)] according to the method described in Example 2. The filtered crystals are purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and toluene:methanol=4:1 as eluent. Melting Point: 203° C. (isopropanol)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07435744B2
Source dataset	uspto-grants-2008_10
ORD ID	ord-c680c423911c4a609026f78c7472d0b5
Source note	uspto-grants-2008_10