HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Benzylpiperidin-1-yl)oxoacetic acid → HCID 69101021, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Benzylpiperidin-1-yl)oxoacetic acid | HCID 16110264 | — |
| Reactant | 5-Amino-1,3-dihydrobenzo[c]isothiazole 2,2-dioxide | HCID 21795144 | — |
| Product | HCID 69101021 | HCID 69101021 | — |
Reaction Steps
The title compound is prepared from (4-benzyl-piperidin-1-yl)-oxo-acetic acid (Example 5b) and 5-amino-1,3-dihydro-2,1-benzisothiazole-2,2-dioxide [J. Het. Chem., 23, 1645. (1986)] according to the method described in Example 2. The filtered crystals are purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and toluene:methanol=4:1 as eluent. Melting Point: 181-182° C. (isopropanol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435744B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-33cc5e72edc041c392b2df9c3096fe1d |
| Source note | uspto-grants-2008_10 |