HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86628255, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloro-4-fluorobenzene-1-sulfonyl chloride | HCID 522846 | — |
| Reactant | 4-Hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone | HCID 68493222 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 86628255 | HCID 86628255 | 34% |
Reaction Steps
In a similar manner to Step 1 of Example 233, 4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0290 g, 0.0628 mmol) was dissolved in acetonitrile (0.650 mL), and the solution was treated with triethylamine (0.0540 mL, 0.390 mmol) and 2-chloro-4-fluorobenzenesulfonyl chloride (0.0447 g, 0.195 mmol) to obtain 4-(2-chloro-4-fluorobenzenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0133 g, yield 34%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745641B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-1465024ab3c346129e248bbe124e6ace |
| Source note | uspto-grants-2010_06 |