6-amino-1,3-benzoxazol-2(3H)-one → HCID 69100287, compound

HRID 2115000Notes

Reaction equation

HRID 2115000 reaction equation
[C:1]([C:5]1[CH:22]=[CH:21][C:8]([CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([C:16](=[O:20])[C:17]([OH:19])=[O:18])[CH2:12][CH2:11]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].N[C:24]1C=CC2NC(=O)OC=2[CH:25]=1>>[CH2:24]([O:18][C:17](=[O:19])[C:16]([N:13]1[CH2:12][CH2:11][CH:10]([CH2:9][C:8]2[CH:21]=[CH:22][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:6][CH:7]=2)[CH2:15][CH2:14]1)=[O:20])[CH3:25]

Participants

3

Reactant 2

HCID 8269896-amino-1,3-benzoxazol-2(3H)-oneHCID 69100016HCID 69100016, compound

Product 1

HCID 69100287HCID 69100287, compound

Procedure

The title compound is prepared from [4-(4-tert-butyl-benzyl)-piperidin-1-yl]-oxo-acetic acid and 6-amino-3H-benzoxazol-2-one according to the method described in Example 2. The filtered crystals are purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and toluene:methanol=4:1 as eluent. Melting Point: 168° C. (diethylether-hexane-diisopropyl ether).

Workup

  1. customThe filtered crystals are purified by column chromatography

Sources & evidence

ORD record
ord-560ded20d9ad4a54ab88c1e1150fa3c0
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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