HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-(Trifluoromethyl)benzyl)piperidine → 2-Oxo-N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-2-[4-(4-trifluoromethyl-benzyl)-piperidin-1-yl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-(Trifluoromethyl)benzyl)piperidine | HCID 4984158 | — |
| Reactant | N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-oxalamic acid | HCID 53306576 | — |
| Product | 2-Oxo-N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-2-[4-(4-trifluoromethyl-benzyl)-piperidin-1-yl]-acetamide | HCID 69100854 | — |
Reaction Steps
The title compound is prepared from 4-(4-trifluoromethyl-benzyl)-piperidine [J. Org. Chem., 64, 3763. (1999)] and N-(2-oxo-2,3-dihydro-benzoxazol-6-yl)-oxalamic acid (Example 43e) according to the method described in Example 43f. The residue is purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and toluene:methanol=4:1 as eluent. Melting Point: 217° C. (isopropanol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435744B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-f687ba0cb2484fbdaf9c6deea85d315f |
| Source note | uspto-grants-2008_10 |