6-amino-3,4-dihydro-2H-1,4-benzoxazin-3-one → HCID 69100321, compound

HRID 2115006Notes

Reaction equation

HRID 2115006 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][CH2:9][C:8](=[O:11])[NH:7][C:6]=2[CH:12]=1.[F:13][C:14]1[CH:31]=[CH:30][C:17]([CH2:18][CH:19]2[CH2:24][CH2:23][N:22]([C:25](=[O:29])[C:26](O)=[O:27])[CH2:21][CH2:20]2)=[CH:16][CH:15]=1>C(OCC)C>[F:13][C:14]1[CH:31]=[CH:30][C:17]([CH2:18][CH:19]2[CH2:20][CH2:21][N:22]([C:25](=[O:29])[C:26]([NH:1][C:2]3[CH:3]=[CH:4][C:5]4[O:10][CH2:9][C:8](=[O:11])[NH:7][C:6]=4[CH:12]=3)=[O:27])[CH2:23][CH2:24]2)=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 27636816-amino-3,4-dihydro-2H-1,4-benzoxazin-3-oneHCID 51342220[4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acid

Product 1

HCID 69100321HCID 69100321, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 6-amino-4H-benzo[1,4]oxazin-3-one [Indian J. Chem. Sect. B, 24, 1263. (1985)] and [4-(4-fluoro-benzyl)-piperidin-1-yl]-oxo-acetic acid (Example 1b) according to the method described in Example 2. Melting Point: 197-200° C. (diethylether)

Sources & evidence

ORD record
ord-00698f3bfc9d447f8b121488ac7b34d4
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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