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Phenyl-piperidin-4-yl-methanol → 2-[4-(Hydroxy-phenyl-methyl)-piperidin-1-yl]-2-oxo-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenyl-piperidin-4-yl-methanol | HCID 339086 | — |
| 反応物 | N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-oxalamic acid | HCID 69100554 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-[4-(Hydroxy-phenyl-methyl)-piperidin-1-yl]-2-oxo-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide | HCID 69100812 | — |
反応手順
The title compound is prepared from N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-oxalamic acid (Example 53b) and phenyl-piperidine-4-yl-methanol [J. Amer. Chem. Soc.,52, 4006. (1930)] according to the method described in Example 1c. Melting Point: 195-197° C. (diethylether)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07435744B2 |
| 出典データセット | uspto-grants-2008_10 |
| ORD ID | ord-2fc867673e2f4b2d934fd7e99e0e3b4d |
| 出典メモ | uspto-grants-2008_10 |