4-(4-Methylphenoxy)piperidine → 2-Oxo-N-(2-oxo-2,3-dihydro-benzothiazol-6-yl)-2-(4-p-tolyloxy-piperidin-1-yl)-acetamide

HRID 2115021Notes

Reaction equation

HRID 2115021 reaction equation
[O:1]=[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([NH:11][C:12](=[O:16])[C:13]([OH:15])=O)=[CH:10][C:4]=2[S:3]1.[C:17]1([CH3:30])[CH:22]=[CH:21][C:20]([O:23][CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[CH:19][CH:18]=1>C(OCC)C>[O:15]=[C:13]([N:27]1[CH2:28][CH2:29][CH:24]([O:23][C:20]2[CH:21]=[CH:22][C:17]([CH3:30])=[CH:18][CH:19]=2)[CH2:25][CH2:26]1)[C:12]([NH:11][C:9]1[CH:8]=[CH:7][C:5]2[NH:6][C:2](=[O:1])[S:3][C:4]=2[CH:10]=1)=[O:16]

Participants

4

Reactant 2

HCID 38374974-(4-Methylphenoxy)piperidineHCID 53306726N-(2-oxo-2,3-dihydro-benzothiazol-6-yl)-oxalamic acid

Product 1

HCID 101363342-Oxo-N-(2-oxo-2,3-dihydro-benzothiazol-6-yl)-2-(4-p-tolyloxy-piperidin-1-yl)-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from N-(2-oxo-2,3-dihydro-benzothiazol-6-yl)-oxalamic acid (Example 61b) and 4-p-tolyloxy-piperidine according to the method described in Example 1c. Melting Point: 215-217° C. (diethylether)

Sources & evidence

ORD record
ord-28727133c0d0459096546bae90c3a99d
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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