N-(3-Cyano-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl)-2-oxo-acetamide → HCID 178522025, compound

HRID 2115032Notes

Reaction equation

HRID 2115032 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:27])[C:11]([N:13]2[CH2:18][CH2:17][CH:16]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[CH2:15][CH2:14]2)=[O:12])[CH:6]=[CH:7][CH:8]=1)#[N:2].[N:28](C[Sn])=[N+:29]=[N-:30]>O>[F:26][C:23]1[CH:24]=[CH:25][C:20]([CH2:19][CH:16]2[CH2:17][CH2:18][N:13]([C:11](=[O:12])[C:10]([NH:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:1]4[NH:30][N:29]=[N:28][N:2]=4)[CH:4]=3)=[O:27])[CH2:14][CH2:15]2)=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 69100240N-(3-Cyano-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl)-2-oxo-acetamideHCID 86593930Azidomethyltin

Product 1

HCID 178522025HCID 178522025, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound is prepared from N-(3-cyano-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-2-oxo-acetamide (Example 14) and azidomethyltin (Aldrich) according to the method described in Example 71. Melting Point: 107-112° C. (water)

Sources & evidence

ORD record
ord-d10358f63a8844f7918b1772869a295c
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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