Diisopropylether hexane → N-(4-Amino-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-2-oxo-acetamide

HRID 2115054Notes

Reaction equation

HRID 2115054 reaction equation
[F:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13](=[O:26])[C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([N+:23]([O-])=O)=[CH:19][CH:18]=3)=[O:15])[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.C(OC(C)C)(C)C.CCCCCC>>[NH2:23][C:20]1[CH:21]=[CH:22][C:17]([NH:16][C:14](=[O:15])[C:13]([N:10]2[CH2:11][CH2:12][CH:7]([CH2:6][C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:28][CH:27]=3)[CH2:8][CH2:9]2)=[O:26])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 21881879Diisopropylether hexaneHCID 691006912-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-N-(4-nitro-phenyl)-2-oxo-acetamide

Product 1

HCID 69100149N-(4-Amino-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-2-oxo-acetamide

Procedure

The title compound is prepared from 2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-N-(4-nitro-phenyl)-2-oxo-acetamide (Example 93) according to the method described in Example 11. Melting Point: 141-143° C. (diisopropylether-hexane).

Sources & evidence

ORD record
ord-b6705f9137fe4d9c93fba086fd901d7e
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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