4-[(2-Methylphenyl)methyl]piperidine → 2-[4-[2-Methyl-benzyl)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide

HRID 2115055Notes

Reaction equation

HRID 2115055 reaction equation
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH:11][C:12](=[O:16])[C:13]([OH:15])=O)[CH:8]=2)[NH:3]1.[CH3:17][C:18]1[CH:30]=[CH:29][CH:28]=[CH:27][C:19]=1[CH2:20][CH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>C(OCC)C>[CH3:17][C:18]1[CH:30]=[CH:29][CH:28]=[CH:27][C:19]=1[CH2:20][CH:21]1[CH2:26][CH2:25][N:24]([C:13](=[O:15])[C:12]([NH:11][C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[NH:3][C:2](=[O:1])[CH2:10]3)=[O:16])[CH2:23][CH2:22]1

Participants

4

Reactant 2

HCID 170394914-[(2-Methylphenyl)methyl]piperidineHCID 53306725N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-oxalamic acid

Product 1

HCID 691009272-[4-[2-Methyl-benzyl)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-oxalamic acid (Example 101b) and 4-(2-methyl-benzyl)-piperidine [J. Org. Chem., 64, 3763. (1999)] according to the method described in Example 1c. Melting Point: 211-213° C. (diethylether)

Sources & evidence

ORD record
ord-6efa9d7ac4034af48a469c2a89e3016c
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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