Thionyl Chloride → HCID 69100567, compound

HRID 2115060Notes

Reaction equation

HRID 2115060 reaction equation
[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:26])[C:15]([NH:17][C:18]2[CH:23]=[CH:22][C:21](O)=[CH:20][C:19]=2[CH3:25])=[O:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:29])=O>C(OCC)C>[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:26])[C:15]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([Cl:29])=[CH:20][C:19]=2[CH3:25])=[O:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 69100082HCID 69100082, compound

Product 1

HCID 69100567HCID 69100567, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 2-(4-benzyl-piperidin-1-yl)-N-(4-hydroxy-methyl-phenyl)-2-oxo-acetamide (Example 117) and thionyl chloride according to the method described in Example 115. Melting Point: 105-108° C. (diethylether)

Sources & evidence

ORD record
ord-6081e4321c9241fbaeda28048e2d9221
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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