4-Aminophthalimide → HCID 69100308, compound

HRID 2115066Notes

Reaction equation

HRID 2115066 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[NH:6][C:5]2=[O:12].[F:13][C:14]1[CH:31]=[CH:30][C:17]([CH2:18][CH:19]2[CH2:24][CH2:23][N:22]([C:25](=[O:29])[C:26](O)=[O:27])[CH2:21][CH2:20]2)=[CH:16][CH:15]=1>C(OCC)C>[O:11]=[C:7]1[C:8]2[C:4](=[CH:3][C:2]([NH:1][C:26](=[O:27])[C:25]([N:22]3[CH2:21][CH2:20][CH:19]([CH2:18][C:17]4[CH:16]=[CH:15][C:14]([F:13])=[CH:31][CH:30]=4)[CH2:24][CH2:23]3)=[O:29])=[CH:10][CH:9]=2)[C:5](=[O:12])[NH:6]1

Participants

4

Reactant 2

HCID 729154-AminophthalimideHCID 51342220[4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acid

Product 1

HCID 69100308HCID 69100308, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 5-amino-isoindole-1,3-dione [Tetrahedron 54, 7485. (1998)] and [4-(4-fluoro-benzyl)-piperidin-1-yl]-oxo-acetic-acid (Example 1b) according to the method described in Example 1c. Melting Point: 226-228° C. (diethylether)

Sources & evidence

ORD record
ord-1d1c51be196240c5a57f08b69cc00257
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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