HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-1,3-dihydrobenzo[c]isothiazole 2,2-dioxide → N-(2,2-Dioxo-2,3-dihydro-1H-2lambda6-benzo[c]isothiazol-5-yl)-2-[4-(4-methyl-benzyl)-piperidin-1-yl)-2-oxo-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-1,3-dihydrobenzo[c]isothiazole 2,2-dioxide | HCID 21795144 | — |
| Reactant | [4-(4-Methyl-benzyl)-piperidin-1-yl)-oxo-acetic acid | HCID 69100073 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | N-(2,2-Dioxo-2,3-dihydro-1H-2lambda6-benzo[c]isothiazol-5-yl)-2-[4-(4-methyl-benzyl)-piperidin-1-yl)-2-oxo-acetamide | HCID 69100322 | — |
Reaction Steps
The title compound is prepared from [4-(4-methyl-benzyl)-piperidin-1-yl]-oxo-acetic acid (Example 119b) and 5-amino-1,3-dihydro-2,1-benzisothiazole-2,2-dioxide according to the method described in Example 94. Melting Point: 186° C. (isopropanol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435744B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-53f2e5927bcd4e30a6fbe117f94af70a |
| Source note | uspto-grants-2008_10 |