4-Benzylpiperidine → 2-(4-Benzyl-piperidin-1-yl)-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-acetamide

HRID 2115087Notes

Reaction equation

HRID 2115087 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:7]=[CH:8][C:9]2[O:14][CH2:13][C:12](=[O:15])[NH:11][C:10]=2[CH:16]=1)=[O:4].[CH2:17]([CH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(OCC)C>[CH2:17]([CH:24]1[CH2:29][CH2:28][N:27]([CH2:2][C:3]([NH:5][C:6]2[CH:7]=[CH:8][C:9]3[O:14][CH2:13][C:12](=[O:15])[NH:11][C:10]=3[CH:16]=2)=[O:4])[CH2:26][CH2:25]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 317384-BenzylpiperidineHCID 242983102-chloro-N-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)acetamide

Product 1

HCID 691004212-(4-Benzyl-piperidin-1-yl)-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 2-chloro-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-acetamide and 4-benzyl-piperidine according to the method described in Example 142b. Melting Point: 220-222° C. (diethylether)

Sources & evidence

ORD record
ord-0d64b62dc31144f299d74d17f49c4691
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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