Diethyl Ether → 2-(4-Phenoxy-methyl-piperidine-1-yl)-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

HRID 2115090Notes

Reaction equation

HRID 2115090 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:16]=[CH:15][C:9]2[NH:10][C:11](=[O:14])[CH2:12][O:13][C:8]=2[CH:7]=1)=[O:4].[O:17]([CH:24]1[CH2:29][CH2:28][N:27](C)[CH2:26][CH2:25]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[CH2:31](OCC)C>>[O:17]([CH:24]1[CH2:25][CH2:26][N:27]([CH2:2][C:3]([NH:5][C:6]2[CH:16]=[CH:15][C:9]3[NH:10][C:11](=[O:14])[CH2:12][O:13][C:8]=3[CH:7]=2)=[O:4])[CH:28]([CH3:31])[CH2:29]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 187229981-Methyl-4-phenoxypiperidineHCID 242982822-chloro-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

Product 1

HCID 691003012-(4-Phenoxy-methyl-piperidine-1-yl)-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

Procedure

The title compound is prepared from 2-chloro-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide (Example 153a) and 4-phenoxy-methyl-piperidine according to the method described in Example 142b. Melting Point: 172-175° C. (diethylether)

Sources & evidence

ORD record
ord-d8b95e48b120421fa6befa0ab730193d
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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