6-amino-1,3-benzoxazol-2(3H)-one → N-(2-oxo-2,3-dihydro-1H-benzoxazol-6-yl)-2-(4-phenoxy-piperidin-1-yl)-acetamide

HRID 2115095Notes

Reaction equation

HRID 2115095 reaction equation
Cl.[O:2]([CH:9]1[CH2:14][CH2:13][N:12]([CH2:15][C:16]([OH:18])=O)[CH2:11][CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[NH2:19][C:20]1[CH:29]=[CH:28][C:23]2[NH:24][C:25](=[O:27])[O:26][C:22]=2[CH:21]=1>C(OCC)C>[O:27]=[C:25]1[NH:24][C:23]2[CH:28]=[CH:29][C:20]([NH:19][C:16](=[O:18])[CH2:15][N:12]3[CH2:11][CH2:10][CH:9]([O:2][C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=4)[CH2:14][CH2:13]3)=[CH:21][C:22]=2[O:26]1

Participants

4

Reactant 2

HCID 8269896-amino-1,3-benzoxazol-2(3H)-oneHCID 69100610HCID 69100610, compound

Product 1

HCID 69100477N-(2-oxo-2,3-dihydro-1H-benzoxazol-6-yl)-2-(4-phenoxy-piperidin-1-yl)-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from (4-phenoxy-piperidin-1-yl)-acetic acid hydrochloride and 6-amino-3H-benzoxazol-2-one according to the method described in Example 161c. Melting Point: 193-195° C. (diethylether)

Sources & evidence

ORD record
ord-ac48d8117a2d4d08a8914e84a49cd9c5
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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