Acetanilide, 2-chloro-4'-nitro- → 1-Piperidineacetamide,4-[(4-fluorophenyl)methyl]-n-(4-nitrophenyl)-

HRID 2115104Notes

Reaction equation

HRID 2115104 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)=[O:4].Cl.[F:16][C:17]1[CH:29]=[CH:28][C:20]([CH2:21][CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[CH:19][CH:18]=1>C(OCC)C>[F:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:21][CH:22]2[CH2:23][CH2:24][N:25]([CH2:2][C:3]([NH:5][C:6]3[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=3)=[O:4])[CH2:26][CH2:27]2)=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 140220Acetanilide, 2-chloro-4'-nitro-HCID 170394924-[(4-Fluorophenyl)methyl]piperidine hydrochloride

Product 1

HCID 691005121-Piperidineacetamide,4-[(4-fluorophenyl)methyl]-n-(4-nitrophenyl)-

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 2-chloro-N-(4-nitro-phenyl)-acetamide and 4-(4-fluoro-benzyl)-piperidine hydrochloride according to the method described in Example 142b. Melting Point: 120-123° C. (diethylether)

Sources & evidence

ORD record
ord-5c74feda9b8741b2ac037efd52c2893f
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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