6-amino-1,3-benzoxazol-2(3H)-one → 6-{2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-ethylamino}-3H-benzoxazol-2-one

Participants

Role	Name	HCID	Charge
Reactant	6-amino-1,3-benzoxazol-2(3H)-one	HCID 826989	—
Reactant	2-Chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone	HCID 69100056	—
Solvent	Diethyl Ether	HCID 3283	—
Product	6-{2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-ethylamino}-3H-benzoxazol-2-one	HCID 10177994	—

Reaction Steps

The title compound is prepared from 2-chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone (Example 197a) and 6-amino-3H-benzoxazol-2-one according to the method described in Example 142b. Melting Point: 202-205° C. (diethylether)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07435744B2
Source dataset	uspto-grants-2008_10
ORD ID	ord-4e6ff7e3ee3347e79a07cc6891eac0f4
Source note	uspto-grants-2008_10