Diethyl Ether → HCID 86593932, compound

HRID 2115123Notes

Reaction equation

HRID 2115123 reaction equation
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]2[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=1.Cl[CH2:14][C:15]([N:17]1[CH2:22][CH2:21][CH:20]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[CH2:19][CH2:18]1)=O.C([O:33]CC)C>>[F:30][C:27]1[CH:28]=[CH:29][C:24]([CH2:23][CH:20]2[CH2:21][CH2:22][N:17]([CH:15]([NH:1][C:2]3[CH:12]=[CH:11][C:5]4[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=4[CH:3]=3)[CH:14]=[O:33])[CH2:18][CH2:19]2)=[CH:25][CH:26]=1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 27641827-amino-3,4-dihydro-2H-1,4-benzoxazin-3-oneHCID 691000562-Chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone

Product 1

HCID 86593932HCID 86593932, compound

Procedure

The title compound is prepared from 7-amino-4H-benzo[1,4]oxazine-3-one and 2-chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone (Example 197a) according to the method described in Example 142b. Melting Point: 156-161° C. (diethylether).

Sources & evidence

ORD record
ord-0caf9f1f3cf64b6d8426bbca790dd046
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

Loading…