1H-Indazol-6-amine → 1-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(1H-indazol-6-yl-amino)-ethanone

HRID 2115125Notes

Reaction equation

HRID 2115125 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][NH:8]2)=[CH:4][CH:3]=1.Cl[CH2:12][C:13]([N:15]1[CH2:20][CH2:19][CH:18]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[CH2:17][CH2:16]1)=[O:14]>>[F:28][C:25]1[CH:26]=[CH:27][C:22]([CH2:21][CH:18]2[CH2:19][CH2:20][N:15]([C:13](=[O:14])[CH2:12][NH:1][C:2]3[CH:10]=[C:9]4[C:5]([CH:6]=[N:7][NH:8]4)=[CH:4][CH:3]=3)[CH2:16][CH2:17]2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 814231H-Indazol-6-amineHCID 691000562-Chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone

Product 1

HCID 691002991-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(1H-indazol-6-yl-amino)-ethanone

Procedure

The title compound is prepared from 6-aminoindazol and 2-chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone (Example 197a) according to the method described in Example

Sources & evidence

ORD record
ord-242ede6207954271a1c53e362950a40f
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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