HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-amino-3,4-dihydro-2H-1,4-benzoxazin-3-one → 1-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl-amino)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-amino-3,4-dihydro-2H-1,4-benzoxazin-3-one | HCID 2763681 | — |
| Reactant | 2-Chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone | HCID 69100056 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl-amino)-ethanone | HCID 69100486 | — |
Reaction Steps
The title compound is prepared from 6-amino-4H-benzo[1,4]oxazin-3-one and 2-chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone (Example 197a) according to the method described in Example 142b. Melting Point: 220-223° C. (diethylether)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435744B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-1286375cebc147fabf4f21d2aac7ed13 |
| Source note | uspto-grants-2008_10 |