Aniline → 1-(4-Benzyl-piperidin-1-yl)-2-phenylamino-ethanone

HRID 2115132Notes

Reaction equation

HRID 2115132 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:9][C:10]([N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:14][CH2:13]1)=[O:11]>C(OCC)C>[CH2:18]([CH:15]1[CH2:14][CH2:13][N:12]([C:10](=[O:11])[CH2:9][NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:17][CH2:16]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 11296081-(4-Benzylpiperidin-1-yl)-2-chloroethan-1-one

Product 1

HCID 394447311-(4-Benzyl-piperidin-1-yl)-2-phenylamino-ethanone

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from aniline and 2-chloro-1-(4-benzyl-piperidin-1-yl)-ethanone (Example 200a) according to the method described in Example 206. Melting Point: 107-109° C. (diethylether)

Sources & evidence

ORD record
ord-8797d0f919f647358f3a13681debf0cc
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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