HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-hydroxybenzimidazole → 5-[2-(4-Benzyl-piperidin-1-yl)-2-oxo-ethylamino]-1,3-dihydro-benzimidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-hydroxybenzimidazole | HCID 66765 | — |
| Reactant | 1-(4-Benzylpiperidin-1-yl)-2-chloroethan-1-one | HCID 1129608 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 5-[2-(4-Benzyl-piperidin-1-yl)-2-oxo-ethylamino]-1,3-dihydro-benzimidazol-2-one | HCID 69100881 | — |
Reaction Steps
The title compound is prepared from 5-amino-1,3-dihydro-benzimidazol-2-one and 2-chloro-1-(4-benzyl-piperidin-1-yl)-ethanone (Example 200a) according to the method described in Example 142b. Melting Point: 237-238° C. (diethylether)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435744B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-7aaa071d70fe4f0f996c6767a218058a |
| Source note | uspto-grants-2008_10 |