6-amino-3,4-dihydroquinolin-2(1H)-one → 6-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-3,4-dihydro-1H-quinolin-2-one

HRID 2115144Notes

Reaction equation

HRID 2115144 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]2.Cl[CH2:14][C:15]([N:17]1[CH2:22][CH2:21][CH:20]([O:23][C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[CH2:19][CH2:18]1)=[O:16]>C(OCC)C>[Cl:30][C:27]1[CH:26]=[CH:25][C:24]([O:23][CH:20]2[CH2:19][CH2:18][N:17]([C:15](=[O:16])[CH2:14][NH:1][C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][CH:11]=3)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]4)[CH2:22][CH2:21]2)=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 49127596-amino-3,4-dihydroquinolin-2(1H)-oneHCID 691000112-Chloro-1-[4-(4-chloro-phenoxy)-piperidin-1-yl]-ethanone

Product 1

HCID 691010256-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-3,4-dihydro-1H-quinolin-2-one

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 6-amino-3,4-dihydro-quinolin-2-one and 2-chloro-1-[4-(4-chloro-phenoxy)-piperidin-1-yl]-ethanone (Example 233a) according to the method described in Example 206. Melting Point: 248-251° C. (diethylether)

Sources & evidence

ORD record
ord-272c7bb140a048938ff49f34b31a5195
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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