HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-amino-3,4-dihydroquinolin-2(1H)-one → 6-{2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-ethylamino}-3,4-dihydro-1H-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-amino-3,4-dihydroquinolin-2(1H)-one | HCID 4912759 | — |
| Reactant | 2-Chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone | HCID 69100056 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-{2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-ethylamino}-3,4-dihydro-1H-quinolin-2-one | HCID 69100682 | — |
Reaction Steps
The title compound is prepared from 6-amino-3,4-dihydro-quinolin-2-one and 2-chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone (Example 197a) according to the method described in Example 206. Melting Point: 197-200° C. (ethyl alcohol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435744B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-cca28e7feefb476988880f7bfe4e83d5 |
| Source note | uspto-grants-2008_10 |