Dimethylformamide → HCID 87780782, compound

Participants

Reaction Steps

The foregoing 2-bromo-4-(4-(4-propylcyclohexyl)cyclohexyl)phenol (250 mg), potassium carbonate (109 mg), and benzyl chloride (135 mg) were mixed, to which were then added DMF (2 ml) and tetrabutylammonium bromide (20 mg), and the mixture was refluxed by heating for 30 minutes. After completion of the reaction, the reaction mixture was added in water and extracted with toluene. The resulting toluene layer was washed with water, rinsed with a sodium hydrogencarbonate aqueous solution, and then dried over anhydrous magnesium sulfate. The solution was concentrated in vacuo and then subjected to isolation and purification by silica gel column chromatography, thereby obtaining a colorless crystal (300 mg) of 2-bromo-4-(4-(4-propylcyclohexyl)cyclohexyl)phenylbenzyl ether.

Provenance & Evidence