p-Toluenesulfonic acid → HCID 58660700, compound

Participants

Reaction Steps

The foregoing ethyl 3-(2-hydroxy-5-(4-(4-propylcyclohexyl)cyclohexyl)phenyl)propionate was dissolved in toluene, to which was then added p-toluenesulfonic acid (100 mg). A Dean-Stark apparatus was attached, and the mixture was stirred under reflux by heating for 3 hours. After completion of the reaction, the reaction mixture was washed with water, rinsed with a sodium hydrogencarbonate aqueous solution, and then dried over anhydrous magnesium sulfate. The solution was concentrated in vacuo and then subjected to isolation and purification by silica gel column chromatography, thereby obtaining a titled compound (100 mg). As a result of a variety of instrumental analyses, it was confirmed that this was the titled compound.

Provenance & Evidence