Ammonia → HCID 178452763, compound

HRID 2115259Notes

Reaction equation

HRID 2115259 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([N:15]2[CH2:20][CH2:19][C:18]3=[C:21]([C:24]([O:26]CC)=O)[NH:22][N:23]=[C:17]3[CH2:16]2)=[N:13][CH:14]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH3:29]>>[C:1]([O:5][C:6]([NH:8][C:9]1[CH:10]=[CH:11][C:12]([N:15]2[CH2:20][CH2:19][C:18]3=[C:21]([C:24]([NH2:29])=[O:26])[NH:22][N:23]=[C:17]3[CH2:16]2)=[N:13][CH:14]=1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178470410HCID 178470410, compound

Product 1

HCID 178452763HCID 178452763, compound

Procedure

The ethyl ester of ethyl 6-(5-tert-butoxycarbonylaminopyridin-2-yl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-3-carboxylate is converted to carboxamide by amidation using a solution of aqueous ammonia, and results in the obtaining of 6-(5-tert-butoxycarbonylaminopyridin-2-yl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-3-carboxamide.

Workup

  1. customresults in the

Sources & evidence

ORD record
ord-702f838658e64f5ca4006e83d4d69a01
Source dataset
uspto-grants-2008_10
Patent number
US07435820B2

Reaction notes

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