Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Propylphosphonic anhydride | HCID 111923 | — |
| Reactant | (4-Chloro-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetic acid | HCID 1876853 | — |
| Reactant | Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylate | HCID 4142526 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59813972 | HCID 59813972 | 93.4% |
Reaction Steps
A solution of (4-Chloro-5-methyl-3-trifluoromethylpyrazol-1-yl)acetic acid (97 mg), triethylamine (0.2 mL) and compound 5 (76 mg) in DMF (2 mL) was stirred at 0° C. and 1-propanephosphonic acid cyclic anhydride (0.55 mL, 50% in EtOAc) was added dropwise. The reaction mixture was stirred another 30 min at 0° C. and directly purified by preparative HPLC to provide the title compound 6 as a pale yellow oil (146 mg, 93%). LCMS: Rf: 4.495 min, M+H+: 459.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07435830B2 |
|---|
| Source dataset | uspto-grants-2008_10 |
|---|
| ORD ID | ord-c3a864f34fb0423ca3547a02df47198e |
|---|
| Source note | uspto-grants-2008_10 |
|---|
