tert-Butyl bromoacetate → {p-Tolyl-[2-(2,2,2-trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl]-amino}-acetic acid

HRID 2115424Notes

Reaction equation

HRID 2115424 reaction equation
[C:1]1([CH3:27])[CH:6]=[CH:5][C:4]([NH:7][S:8]([C:11]2[CH:20]=[C:19]3[C:14]([CH2:15][CH2:16][N:17]([C:21](=[O:26])[C:22]([F:25])([F:24])[F:23])[CH2:18]3)=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:3][CH:2]=1.Br[CH2:29][C:30]([O:32]C(C)(C)C)=[O:31]>>[C:1]1([CH3:27])[CH:6]=[CH:5][C:4]([N:7]([CH2:29][C:30]([OH:32])=[O:31])[S:8]([C:11]2[CH:20]=[C:19]3[C:14]([CH2:15][CH2:16][N:17]([C:21](=[O:26])[C:22]([F:23])([F:25])[F:24])[CH2:18]3)=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 38128732-(2,2,2-Trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid p-tolylamide

Product 1

HCID 58978358{p-Tolyl-[2-(2,2,2-trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl]-amino}-acetic acid

Procedure

prepared by reaction of 2-(2,2,2-trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid p-tolylamide with tert-butyl bromoacetate

Sources & evidence

ORD record
ord-b547be537d5a4a6781c1035b73c27727
Source dataset
uspto-grants-2008_10
Patent number
US07435815B2

Reaction notes

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