Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | HCID 22258909 | HCID 22258909 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 22258735 | HCID 22258735 | 96% |
Reaction Steps
A mixture of 2-{[6-[2-(benzyloxy)phenyl]-3-cyano-4-(methylsulfinyl)-2-pyridinyl]oxy}acetamide (300 mg, 0.71 mmol) and morpholine (1.0 mL) was stirred at 130° C. for 1 hr, and then water was added. The resulting precipitates were collected by filtration and dried under reduced pressure to give 2-{[6-[2-(benzyloxy)phenyl]-3-cyano-4-(4-morpholinyl)-2-pyridinyl]oxy}acetamide as a yellow solid (304 mg, yield; 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07435743B2 |
|---|
| Source dataset | uspto-grants-2008_10 |
|---|
| ORD ID | ord-d596ddb1d4b641e996b071dab0891df1 |
|---|
| Source note | uspto-grants-2008_10 |
|---|
