P-Anisidine → HCID 59813198, compound

Participants

Reaction Steps

6-(2-Methylaminopyridin-4-yloxy)-1-naphthoic acid (170 mg, 0.58 mmol), p-anisidine (107 mg, 0.87 mmol), DIPEA (149 mg, 1.16 mmol) and TBTU (223 mg, 0.69 mmol) were combined in DMF (3.0 mL) and the reaction mixture was stirred at RT for 16 h, quenched by addition of a 6M aqueous NaOH solution. The precipitate was filtered off, treated with DCM, sonicated. The title compound was isolated by filtration. MS (ESI, pos. ion) m/z: 400.1 (M+1). Mass Calc'd for C24H21N3O3: 399.45.

Provenance & Evidence