反应详情

To a stirred solution of tert-butyl 6-methoxypyridin-3-ylcarbamate (14.4 g, 64.2 mmol) in MeOH (95 mL) was added methyl iodide (14.6 g, 103 mmol). The reaction mixture was heated at reflux for 16 h, cooled to RT and concentrated down. The residue was purified by silica gel chromatography to give the title compound.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 16 h
3. concentrationconcentrated down
4. customThe residue was purified by silica gel chromatography