3-(Trifluoromethoxy)aniline → HCID 58732909, compound

HRID 2115835Notes

Reaction equation

HRID 2115835 reaction equation
[C:1]([C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:12]=[C:13]3[C:18](=[CH:19][CH:20]=2)[C:17]([C:21](Cl)=[O:22])=[CH:16][CH:15]=[CH:14]3)[CH:7]=[CH:6][N:5]=1)(=[O:3])[NH2:2].[F:24][C:25]([F:35])([F:34])[O:26][C:27]1[CH:28]=[C:29]([CH:31]=[CH:32][CH:33]=1)[NH2:30]>>[F:24][C:25]([F:34])([F:35])[O:26][C:27]1[CH:28]=[C:29]([NH:30][C:21]([C:17]2[CH:16]=[CH:15][CH:14]=[C:13]3[C:18]=2[CH:19]=[CH:20][C:11]([O:10][C:8]2[CH:7]=[CH:6][N:5]=[C:4]([C:1]([NH2:2])=[O:3])[CH:9]=2)=[CH:12]3)=[O:22])[CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 737533-(Trifluoromethoxy)anilineHCID 86062305HCID 86062305, compound

Product 1

HCID 58732909HCID 58732909, compound

Procedure

6-(2-carbamoylpyrdin-4-yloxy)-1-napthoyl chloride (step b, 150 mg g, 0.41 mmol) was reacted with 3-trifluoromethoxyaniline 56 μL, 0.41 mmol, Aldrich) under the conditions of Example 421 Step c to furnish the title compound as a yellow solid. MS (ESI, pos. ion) m/z: 468.1 (M+1). Mass Calc'd for C24H16F3N3O4: 467.40.

Sources & evidence

ORD record
ord-c66e3a4d51a747ac81c834998ed2dc26
Source dataset
uspto-grants-2008_10
Patent number
US07435823B2

Reaction notes

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