HCID 24823730, compound → 7-Hydroxy-quinoline-4-carboxylic acid

HRID 2115863Notes

Reaction equation

HRID 2115863 reaction equation
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:13]([O:15]C)=[O:14])=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1>C(Cl)Cl.B(Br)(Br)Br>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:13]([OH:15])=[O:14])=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 24823730HCID 24823730, compound

Product 1

HCID 1357833057-Hydroxy-quinoline-4-carboxylic acid

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 25134Boron tribromideSolvent

Procedure

To a cooled (0° C.) solution of methyl 7-methoxyquinoline-4-carboxylate (378 mg, 1.74 mmol) in CH2Cl2, BBr3 (9 mL, excess) was added and the reaction mixture stirred and warmed to RT. After 4 days, the mixture was poured into ice and the yellow solid collected as the title compound.

Workup

  1. additionwas added
  2. additionthe mixture was poured into ice
  3. customthe yellow solid collected as the title compound

Sources & evidence

ORD record
ord-541cf3fe1c5140baa62175d6055fc96f
Source dataset
uspto-grants-2008_10
Patent number
US07435823B2

Reaction notes

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